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Clonal expansion and epigenetic inheritance of long-lasting NK cell memory

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Item Type:Article
Title:Clonal expansion and epigenetic inheritance of long-lasting NK cell memory
Creators Name:Rückert, T. and Lareau, C.A. and Mashreghi, M.F. and Ludwig, L.S. and Romagnani, C.
Abstract:Clonal expansion of cells with somatically diversified receptors and their long-term maintenance as memory cells is a hallmark of adaptive immunity. Here, we studied pathogen-specific adaptation within the innate immune system, tracking natural killer (NK) cell memory to human cytomegalovirus (HCMV) infection. Leveraging single-cell multiomic maps of ex vivo NK cells and somatic mitochondrial DNA mutations as endogenous barcodes, we reveal substantial clonal expansion of adaptive NK cells in HCMV(+) individuals. NK cell clonotypes were characterized by a convergent inflammatory memory signature enriched for AP1 motifs superimposed on a private set of clone-specific accessible chromatin regions. NK cell clones were stably maintained in specific epigenetic states over time, revealing that clonal inheritance of chromatin accessibility shapes the epigenetic memory repertoire. Together, we identify clonal expansion and persistence within the human innate immune system, suggesting that these mechanisms have evolved independent of antigen-receptor diversification.
Keywords:Clonal Selection, Epigenetics in Immune Cells, NK Cells, Viral Infection
Source:Nature Immunology
Publisher:Nature Publishing Group
Page Range:1551-1563
Date:November 2022
Official Publication:https://doi.org/10.1038/s41590-022-01327-7
PubMed:View item in PubMed

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