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Regulation of early cerebellar development

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Item Type:Review
Title:Regulation of early cerebellar development
Creators Name:Lowenstein, E. and Cui, K. and Hernandez-Miranda, L.R.
Abstract:The study of cerebellar development has been at the forefront of neuroscience since the pioneering work of Wilhelm His Sr., Santiago Ramón y Cajal, and many others since the 19(th) century. They laid the foundation to identify the circuitry of the cerebellum, already revealing its stereotypic three-layered cortex and discerning several of its neuronal components. Their work was fundamental in the acceptance of the neuron doctrine, which acknowledges the key role of individual neurons in forming the basic units of the nervous system. Increasing evidence shows that the cerebellum plays a variety of homeostatic and higher order neuronal functions beyond the mere control of motor behavior. Over the last three decades, many studies have revealed the molecular machinery that regulates distinct aspects of cerebellar development, from the establishment of a cerebellar anlage in the posterior brain to the identification of cerebellar neuron diversity at the single cell level. In this review, we focus on summarizing our current knowledge on early cerebellar development with a particular emphasis on the molecular determinants that secure neuron specification and contribute to the diversity of cerebellar neurons.
Keywords:Cerebellar Development, Neuronal Specification, Progenitor Niches, Rhombic Lip, Transcription Factors, Ventricular Zone
Source:FEBS Journal
Page Range:2786-2804
Date:June 2022
Additional Information:Copyright © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Official Publication:https://doi.org/10.1111/febs.16426
PubMed:View item in PubMed

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