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Technologies for profiling the impact of genomic variants on transcription factor binding

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Item Type:Article
Title:Technologies for profiling the impact of genomic variants on transcription factor binding
Creators Name:Leiz, J. and Rutkiewicz, M. and Birchmeier, C. and Heinemann, U. and Schmidt-Ott, K.M.
Abstract:Transcription factors (TFs) bind DNA in a sequence-specific manner and thereby regulate target gene expression. TF binding and its regulatory activity is highly context dependent, and is not only determined by specific cell types or differentiation stages but also relies on other regulatory mechanisms, such as DNA and chromatin modifications. Interactions between TFs and their DNA binding sites are critical mediators of phenotypic variation and play important roles in the onset of disease. A continuously growing number of studies therefore attempts to elucidate TF:DNA interactions to gain knowledge about regulatory mechanisms and disease-causing variants. Here we summarize how TF-binding characteristics and the impact of variants can be investigated, how bioinformatic tools can be used to analyze and predict TF:DNA binding, and what additional information can be obtained from the TF protein structure
Keywords:Transcriptional Regulation, Genomic Variants, TF:DNA Binding, Binding Prediction
Source:Medizinische Genetik
Publisher:de Gruyter
Page Range:147-155
Date:14 August 2021
Official Publication:https://doi.org/10.1515/medgen-2021-2073

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