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Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks

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Item Type:Article
Title:Association between erythrocyte dynamics and vessel remodelling in developmental vascular networks
Creators Name:Zhou, Q. and Perovic, T. and Fechner, I. and Edgar, L.T. and Hoskins, P.R. and Gerhardt, H. and Krüger, T. and Bernabeu, M.O.
Abstract:Sprouting angiogenesis is an essential vascularization mechanism consisting of sprouting and remodelling. The remodelling phase is driven by rearrangements of endothelial cells (ECs) within the post-sprouting vascular plexus. Prior work has uncovered how ECs polarize and migrate in response to flow-induced wall shear stress (WSS). However, the question of how the presence of erythrocytes (widely known as red blood cells (RBCs)) and their impact on haemodynamics affect vascular remodelling remains unanswered. Here, we devise a computational framework to model cellular blood flow in developmental mouse retina. We demonstrate a previously unreported highly heterogeneous distribution of RBCs in primitive vasculature. Furthermore, we report a strong association between vessel regression and RBC hypoperfusion, and identify plasma skimming as the driving mechanism. Live imaging in a developmental zebrafish model confirms this association. Taken together, our results indicate that RBC dynamics are fundamental to establishing the regional WSS differences driving vascular remodelling via their ability to modulate effective viscosity.
Keywords:Angiogenesis, Haemodynamics, Microcirculation, Vascular Remodelling, Wall Shear Stress, Red Blood Cells, Animals, Mice, Zebrafish
Source:Journal of the Royal Society Interface
Publisher:Royal Society of London
Page Range:20210113
Date:June 2021
Official Publication:https://doi.org/10.1098/rsif.2021.0113
PubMed:View item in PubMed
Related to:
https://edoc.mdc-berlin.de/18973/Preprint version

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