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Generation of 20 human induced pluripotent stem cell lines from patients with focal segmental glomerulosclerosis (FSGS)

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Item Type:Editorial
Title:Generation of 20 human induced pluripotent stem cell lines from patients with focal segmental glomerulosclerosis (FSGS)
Creators Name:Cernoch, J., Fisch, T., Fischer, I., Fischer, K., Iwanska, A., Krüger, N., Küchler, J., Schaar, C., Schommer, S., Telugu, N., Miller, D., Fernández Vallone, V., Kurtz, A., Reinke, P., Diecke, S. and Stachelscheid, H.
Abstract:Focal segmental glomerulosclerosis (FSGS) is a major cause of familial nephrotic syndrome. We generated 20 induced pluripotent stem cell lines from patients diagnosed with FSGS. The iPSC lines include 8 female and 12 male lines and cover a donor age range from 31 to 78. The lines were generated from peripheral blood mononuclear cells by integration-free reprogramming using Sendai virus vectors. Cell lines were fully characterized regarding their pluripotency and differentiation potential, and quality controlled for karyotypic integrity, identity and clearance of reprogramming vectors. The generated cell lines represent a valuable tool for disease modelling and drug development for FSGS.
Keywords:Cell Line, Glomerulosclerosis, Focal Segmental, Induced Pluripotent Stem Cells, Mononuclear Leukocytes, Sendai virus, Animals, Mice
Source:Stem Cell Research
ISSN:1873-5061
Publisher:Elsevier
Volume:54
Page Range:102406
Date:July 2021
Official Publication:https://doi.org/10.1016/j.scr.2021.102406
PubMed:View item in PubMed

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