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| Item Type: | Article |
|---|---|
| Title: | SIGLEC1 (CD169): a marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients |
| Creators Name: | Ostendorf, L. and Dittert, P. and Biesen, R. and Duchow, A. and Stiglbauer, V. and Ruprecht, K. and Bellmann-Strobl, J. and Seelow, D. and Stenzel, W. and Niesner, R.A. and Hauser, A.E. and Paul, F. and Radbruch, H. |
| Abstract: | We aimed to evaluate SIGLEC1 (CD169) as a biomarker in multiple sclerosis (MS) and Neuromyelitis optica spectrum disorder (NMOSD) and to evaluate the presence of SIGLEC1(+) myeloid cells in demyelinating diseases. We performed flow cytometry-based measurements of SIGLEC1 expression on monocytes in 86 MS patients, 41 NMOSD patients and 31 healthy controls. Additionally, we histologically evaluated the presence of SIGLEC1(+) myeloid cells in acute and chronic MS brain lesions as well as other neurological diseases. We found elevated SIGLEC1 expression in 16/86 (18.6%) MS patients and 4/41 (9.8%) NMOSD patients. Almost all MS patients with high SIGLEC1 levels received exogenous interferon beta as an immunomodulatory treatment and only a small fraction of MS patients without interferon treatment had increased SIGLEC1 expression. In our cohort, SIGLEC1 expression on monocytes was—apart from those patients receiving interferon treatment - not significantly increased in patients with MS and NMOSD, nor were levels associated with more severe disease. SIGLEC1(+) myeloid cells were abundantly present in active MS lesions as well as in a range of acute infectious and malignant diseases of the central nervous system, but not chronic MS lesions. The presence of SIGLEC1(+) myeloid cells in brain lesions could be used to investigate the activity in an inflammatory CNS lesion. |
| Keywords: | Biomarkers, Brain, Case-Control Studies, Flow Cytometry, Interferon-beta, Multiple Sclerosis, Sialic Acid Binding Ig-like Lectin 1 |
| Source: | Scientific Reports |
| ISSN: | 2045-2322 |
| Publisher: | Nature Publishing Group |
| Volume: | 11 |
| Number: | 1 |
| Page Range: | 10299 |
| Date: | 13 May 2021 |
| Official Publication: | https://doi.org/10.1038/s41598-021-89786-0 |
| PubMed: | View item in PubMed |
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