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Sodium and its manifold impact on our immune system

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Item Type:Article
Title:Sodium and its manifold impact on our immune system
Creators Name:Jobin, K. and Müller, D.N. and Jantsch, J. and Kurts, C.
Abstract:The Western diet is rich in salt, and a high salt diet (HSD) is suspected to be a risk factor for cardiovascular diseases. It is now widely accepted that an experimental HSD can stimulate components of the immune system, potentially exacerbating certain autoimmune diseases, or alternatively, improving defenses against certain infections, such as cutaneous leishmaniasis. However, recent findings show that an experimental HSD may also aggravate other infections (e.g., pyelonephritis or systemic listeriosis). Here, we discuss the modulatory effects of a HSD on the microbiota, metabolic signaling, hormonal responses, local sodium concentrations, and their effects on various immune cell types in different tissues. We describe how these factors are integrated, resulting either in immune stimulation or suppression in various tissues and disease settings.
Keywords:Sodium, NFAT5, Macrophages, T Cells, Neutrophils, Microbiome, Pyelonephritis, Leishmaniasis, Antimicrobial Defense, Listeriosis, Glucocorticoids, Animals, Mice
Source:Trends in Immunology
ISSN:1471-4906
Publisher:Elsevier
Volume:42
Number:6
Page Range:469-479
Date:June 2021
Official Publication:https://doi.org/10.1016/j.it.2021.04.002
PubMed:View item in PubMed

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