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Functional imaging using fluorine ((19)F) MR methods: basic concepts

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Item Type:Article
Title:Functional imaging using fluorine ((19)F) MR methods: basic concepts
Creators Name:Waiczies, S. and Prinz, C. and Starke, L. and Millward, J.M. and Delgado, P.R. and Rosenberg, J. and Nazaré, M. and Waiczies, H. and Pohlmann, A. and Niendorf, T.
Abstract:Kidney-associated pathologies would greatly benefit from noninvasive and robust methods that can objectively quantify changes in renal function. In the past years there has been a growing incentive to develop new applications for fluorine ((19)F) MRI in biomedical research to study functional changes during disease states. (19)F MRI represents an instrumental tool for the quantification of exogenous (19)F substances in vivo. One of the major benefits of (19)F MRI is that fluorine in its organic form is absent in eukaryotic cells. Therefore, the introduction of exogenous (19)F signals in vivo will yield background-free images, thus providing highly selective detection with absolute specificity in vivo. Here we introduce the concept of (19)F MRI, describe existing challenges, especially those pertaining to signal sensitivity, and give an overview of preclinical applications to illustrate the utility and applicability of this technique for measuring renal function in animal models. This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.
Keywords:Magnetic Resonance Imaging (MRI), Fluorine ((19)F), Kidney, Inflammation, Tissue Oxygenation, Animals
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
Publisher:Springer / Humana Press
Page Range:279-299
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_17
PubMed:View item in PubMed
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