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Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors

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Item Type:Article
Title:Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors
Creators Name:Giugliano, G. and Laurenzano, E. and Rengo, C. and De Rosa, G. and Brevetti, L. and Sannino, A. and Perrino, C. and Chiariotti, L. and Schiattarella, G.G. and Serino, F. and Ferrone, M. and Scudiero, F. and Carbone, A. and Sorropago, A. and Amato, B. and Trimarco, B. and Esposito, G.
Abstract:BACKGROUND: Abdominal aortic aneurysm (AAA) is a frequent cause of death among elderly. Patients affected by lower extremity peripheral arterial disease (LE-PAD) seem to be particularly at high risk for AAA. We aimed this study at assessing the prevalence and the clinical predictors of the presence of AAA in a homogeneous cohort of LE-PAD patients affected by intermittent claudication. METHODS: We performed an abdominal ultrasound in 213 consecutive patients with documented LE-PAD (ankle/brachial index ≤ 0.90) attending our outpatient clinic for intermittent claudication. For each patient we registered cardiovascular risk factors and comorbidities, and measured neutrophil count. RESULTS: The ultrasound was inconclusive in 3 patients (1.4%), thus 210 patients (169 males, 41 females, mean age 65.9 ± 9.8 yr) entered the study. Overall, AAA was present in 19 patients (9.0%), with a not significant higher prevalence in men than in women (10.1% vs 4.9%, p = 0.300). Patients with AAA were older (71.2 ± 7.0 vs 65.4 ± 9.9 years, p = 0.015), were more likely to have hypertension (94.7% vs 71.2%, p = 0.027), and greater neutrophil count (5.5 [4.5 - 6.2] vs 4.1 [3.2 - 5.5] x 10(3)/μL, p = 0.010). Importantly, the c-statistic for neutrophil count (0.73, 95% CI 0.60 - 0.86, p = 0.010) was higher than that for age (0.67, CI 0.56-0.78, p = 0.017). The prevalence of AAA in claudicant patients with a neutrophil count ≥ 5.1 x 10(3)/μL (cut-off identified at ROC analysis) was as high as 29.0%. CONCLUSIONS: Prevalence of AAA in claudicant patients is much higher than that reported in the general population. Ultrasound screening should be considered in these patients, especially in those with an elevated neutrophil count.
Keywords:Abdominal Aortic Aneurysm, Neutrophil Count, Abdominal Aortic Aneurysm, Ankle Brachial Index, Intermittent Claudication
Source:BMC Surgery
Publisher:BioMed Central
Number:Suppl 1
Page Range:S17
Date:15 November 2012
Official Publication:https://doi.org/10.1186/1471-2482-12-S1-S17
PubMed:View item in PubMed

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