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Analysis of renal diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) models

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Item Type:Article
Title:Analysis of renal diffusion-weighted imaging (DWI) using apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) models
Creators Name:Jerome, N.P. and Periquito, J.S.
Abstract:Analysis of renal diffusion-weighted imaging (DWI) data to derive markers of tissue properties requires careful consideration of the type, extent, and limitations of the acquired data. Alongside data quality and general suitability for quantitative analysis, choice of diffusion model, fitting algorithm, and processing steps can have consequences for the precision, accuracy, and reliability of derived diffusion parameters. Here we introduce and discuss important steps for diffusion-weighted image processing, and in particular give example analysis protocols and pseudo-code for analysis using the apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) models. Following an overview of general principles, we provide details of optional steps, and steps for validation of results. Illustrative examples are provided, together with extensive notes discussing wider context of individual steps, and notes on potential pitfalls.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concepts and experimental procedure.
Keywords:MRI, Kidney, Diffusion, Diffusion-Weighted Imaging (DWI), Apparent Diffusion Coefficient (ADC), Intravoxel Incoherent Motion (IVIM), Analysis, Algorithm, Animals
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
ISSN:1064-3745
ISBN:978-1-0716-0977-4
Publisher:Springer / Humana Press
Volume:2216
Page Range:611-635
Date:2021
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_37
PubMed:View item in PubMed
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https://edoc.mdc-berlin.de/19922/Book

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