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Analysis protocols for MRI mapping of the blood oxygenation-sensitive parameters T(2)* and T(2) in the kidney

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Item Type:Article
Title:Analysis protocols for MRI mapping of the blood oxygenation-sensitive parameters T(2)* and T(2) in the kidney
Creators Name:Periquito, J.S. and Starke, L. and Santos, C.M. and Freitas, A.C. and Loução, N. and Polo, P.G. and Nunes, R.G. and Niendorf, T. and Pohlmann, A.
Abstract:Renal hypoxia is generally accepted as a key pathophysiologic event in acute kidney injury of various origins and has also been suggested to play a role in the development of chronic kidney disease. Here we describe step-by-step data analysis protocols for MRI monitoring of renal oxygenation in rodents via the deoxyhemoglobin concentration sensitive MR parameters T(2)* and T(2)-a contrast mechanism known as the blood oxygenation level dependent (BOLD) effect.This chapter describes how to use the analysis tools provided by vendors of animal and clinical MR systems, as well as how to develop an analysis software. Aspects covered are: data quality checks, data exclusion, model fitting, fitting algorithm, starting values, effects of multiecho imaging, and result validation.This chapter is based upon work from the PARENCHIMA COST Action, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.
Keywords:Magnetic Resonance Imaging (MRI), Kidney, T(2), T(2)*, BOLD, Animals
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
Publisher:Springer / Humana Press
Page Range:591-610
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_36
PubMed:View item in PubMed
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