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Renal MRI diffusion: experimental protocol

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Item Type:Article
Title:Renal MRI diffusion: experimental protocol
Creators Name:Periquito, J.S. and Meier, M. and Niendorf, T. and Pohlmann, A. and Jerome, N.P.
Abstract:Renal diffusion-weighted imaging (DWI) can be used to obtain information on the microstructure of kidney tissue, and has the potential to provide MR-biomarkers for functional renal imaging. Here we describe in a step-by-step experimental protocol the MRI method for measuring renal diffusion coefficients in rodents using ADC or IVIM models. Both methods provide quantification of renal diffusion coefficients; however, IVIM, a more complex model, allows for the calculation of the pseudodiffusion and fraction introduced by tissue vascular and tubular components. DWI provides information of renal microstructure contributing to the understanding of the physiology and the underlying processes that precede the beginning of pathologies.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This experimental protocol chapter is complemented by two separate chapters describing the basic concept and data analysis.
Keywords:Magnetic Resonance Imaging (MRI), Kidney, Diffusion, ADC, IVIM, Animals, Mice
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
Publisher:Springer / Humana Press
Page Range:419-428
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_24
PubMed:View item in PubMed
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