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| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Title: | Quantitative assessment of renal perfusion and oxygenation by invasive probes: basic concepts | ||||
| Creators Name: | Cantow, K. and Evans, R.G. and Grosenick, D. and Gladytz, T. and Niendorf, T. and Flemming, B. and Seeliger, E. | ||||
| Abstract: | Renal tissue hypoperfusion and hypoxia are early key elements in the pathophysiology of acute kidney injury of various origins, and may also promote progression from acute injury to chronic kidney disease. Here we describe basic principles of methodology to quantify renal hemodynamics and tissue oxygenation by means of invasive probes in experimental animals. Advantages and disadvantages of the various methods are discussed in the context of the heterogeneity of renal tissue perfusion and oxygenation.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by a separate chapter describing the experimental procedure and data analysis. | ||||
| Keywords: | Renal Hemodynamics and Oxygenation, In Vivo Methods, Quantitative Invasive Probes, Animals | ||||
| Source: | Methods in Molecular Biology | ||||
| Series Name: | Methods in Molecular Biology | ||||
| Title of Book: | Preclinical MRI of the kidney : methods and protocols | ||||
| ISSN: | 1064-3745 | ||||
| ISBN: | 978-1-0716-0977-4 | ||||
| Publisher: | Springer / Humana Press | ||||
| Volume: | 2216 | ||||
| Page Range: | 89-107 | ||||
| Date: | 2021 | ||||
| Official Publication: | https://doi.org/10.1007/978-1-0716-0978-1_6 | ||||
| PubMed: | View item in PubMed | ||||
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