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Preparation and monitoring of small animals in renal MRI

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Item Type:Article
Title:Preparation and monitoring of small animals in renal MRI
Creators Name:Kaucsar, T., Hosszu, A., Seeliger, E., Reimann, H.M. and Fekete, A.
Abstract:Renal diseases remain devastating illnesses with unacceptably high rates of mortality and morbidity worldwide. Animal models are essential tools to better understand the pathomechanism of kidney-related illnesses and to develop new, successful therapeutic strategies. Magnetic resonance imaging (MRI) has been actively explored in the last decades for assessing renal function, perfusion, tissue oxygenation as well as the degree of fibrosis and inflammation. This chapter aims to provide an overview of the preparation and monitoring of small animals before, during, and after surgical interventions or MR imaging. Standardization of experimental settings such as body temperature or hydration of animals and minimizing pain and distress are essential for diminishing nonexperimental variables as well as for conducting ethical research.This publication is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers.
Keywords:Magnetic Resonance Imaging (MRI), Kidney, Rodent Surgery, Anesthesia, Animals, Mice, Rats
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI of the kidney : methods and protocols
ISSN:1064-3745
ISBN:978-1-0716-0977-4
Publisher:Springer / Humana Press
Volume:2216
Page Range:45-55
Date:2021
Official Publication:https://doi.org/10.1007/978-1-0716-0978-1_3
PubMed:View item in PubMed
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