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| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Title: | Variability of an early developmental cell population underlies stochastic laterality defects | ||||
| Creators Name: | Moreno-Ayala, R. and Olivares-Chauvet, P. and Schäfer, R. and Junker, J.P. | ||||
| Abstract: | Embryonic development seemingly proceeds with almost perfect precision. However, it is largely unknown how much underlying microscopic variability is compatible with normal development. Here, we quantify embryo-to-embryo variability in vertebrate development by studying cell number variation in the zebrafish endoderm. We notice that the size of a sub-population of the endoderm, the dorsal forerunner cells (DFCs, which later form the left-right organizer), exhibits significantly more embryo-to-embryo variation than the rest of the endoderm. We find that, with incubation of the embryos at elevated temperature, the frequency of left-right laterality defects is increased drastically in embryos with a low number of DFCs. Furthermore, we observe that these fluctuations have a large stochastic component among fish of the same genetic background. Hence, a stochastic variation in early development leads to a remarkably strong macroscopic phenotype. These fluctuations appear to be associated with maternal effects in the specification of the DFCs. | ||||
| Keywords: | Early Development, Phenotypic Variability, Dorsal Forerunner Cells, Left-Right Asymmetry, Heart Laterality, Maternal Effects, Animals, Zebrafish | ||||
| Source: | Cell Reports | ||||
| ISSN: | 2211-1247 | ||||
| Publisher: | Cell Press / Elsevier | ||||
| Volume: | 34 | ||||
| Number: | 2 | ||||
| Page Range: | 108606 | ||||
| Date: | 12 January 2021 | ||||
| Official Publication: | https://doi.org/10.1016/j.celrep.2020.108606 | ||||
| PubMed: | View item in PubMed | ||||
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