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| Item Type: | Article | ||||
|---|---|---|---|---|---|
| Title: | Microscopy with undetected photons in the mid-infrared | ||||
| Creators Name: | Kviatkovsky, I. and Chrzanowski, H.M. and Avery, E.G. and Bartolomaeus, H. and Ramelow, S. | ||||
| Abstract: | Owing to its capacity for unique (bio)-chemical specificity, microscopy with mid-infrared (IR) illumination holds tremendous promise for a wide range of biomedical and industrial applications. The primary limitation, however, remains detection, with current mid-IR detection technology often marrying inferior technical capabilities with prohibitive costs. Here, we experimentally show how nonlinear interferometry with entangled light can provide a powerful tool for mid-IR microscopy while only requiring near-IR detection with a silicon-based camera. In this proof-of-principle implementation, we demonstrate widefield imaging over a broad wavelength range covering 3.4 to 4.3 μm and demonstrate a spatial resolution of 35 μm for images containing 650 resolved elements. Moreover, we demonstrate that our technique is suitable for acquiring microscopic images of biological tissue samples in the mid-IR. These results form a fresh perspective for potential relevance of quantum imaging techniques in the life sciences. | ||||
| Keywords: | Animals, Mice | ||||
| Source: | Science Advances | ||||
| ISSN: | 2375-2548 | ||||
| Publisher: | American Association for the Advancement of Science | ||||
| Volume: | 6 | ||||
| Number: | 42 | ||||
| Page Range: | eabd0264 | ||||
| Date: | 14 October 2020 | ||||
| Official Publication: | https://doi.org/10.1126/sciadv.abd0264 | ||||
| PubMed: | View item in PubMed | ||||
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