Helmholtz Gemeinschaft


mRNAs, proteins and the emerging principles of gene expression control

Item Type:Review
Title:mRNAs, proteins and the emerging principles of gene expression control
Creators Name:Buccitelli, C. and Selbach, M.
Abstract:Gene expression involves transcription, translation and the turnover of mRNAs and proteins. The degree to which protein abundances scale with mRNA levels and the implications in cases where this dependency breaks down remain an intensely debated topic. Here we review recent mRNA-protein correlation studies in the light of the quantitative parameters of the gene expression pathway, contextual confounders and buffering mechanisms. Although protein and mRNA levels typically show reasonable correlation, we describe how transcriptomics and proteomics provide useful non-redundant readouts. Integrating both types of data can reveal exciting biology and is an essential step in refining our understanding of the principles of gene expression control.
Keywords:Computational Biology, Gene Expression Regulation, Messenger RNA, Protein Biosynthesis, Proteins, Proteome, Transcriptome
Source:Nature Reviews Genetics
Publisher:Nature Publishing Group
Page Range:630-644
Date:October 2020
Official Publication:https://doi.org/10.1038/s41576-020-0258-4
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library