The sensory coding of warm perception

Paricio-Montesinos, R.; Schwaller, F.; Udhayachandran, A.; Rau, F.; Walcher, J.; Evangelista, R.; Vriens, J.; Voets, T.; Poulet, J.F.A.; Lewin, G.R.

The sensory coding of warm perception

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Item Type:	Article
Title:	The sensory coding of warm perception
Creators Name:	Paricio-Montesinos, R., Schwaller, F., Udhayachandran, A., Rau, F., Walcher, J., Evangelista, R., Vriens, J., Voets, T., Poulet, J.F.A. and Lewin, G.R.
Abstract:	Humans detect skin temperature changes that are perceived as warm or cool. Like humans, mice report forepaw skin warming with perceptual thresholds of less than 1°C and do not confuse warm with cool. We identify two populations of polymodal C-fibers that signal warm. Warm excites one population, whereas it suppresses the ongoing cool-driven firing of the other. In the absence of the thermosensitive TRPM2 or TRPV1 ion channels, warm perception was blunted, but not abolished. In addition, trpv1:trpa1:trpm3(-/-) triple-mutant mice that cannot sense noxious heat detected skin warming, albeit with reduced sensitivity. In contrast, loss or local pharmacological silencing of the cool-driven TRPM8 channel abolished the ability to detect warm. Our data are not reconcilable with a labeled line model for warm perception, with receptors firing only in response to warm stimuli, but instead support a conserved dual sensory model to unambiguously detect skin warming in vertebrates.
Keywords:	Perception, Sensory Coding, Warm, Thermal Transduction, Nociception, Polymodal, C-Fiber, TRP Channels, Animals, Mice
Source:	Neuron
ISSN:	0896-6273
Publisher:	Cell Press
Volume:	106
Number:	5
Page Range:	830-841
Date:	3 June 2020
Official Publication:	https://doi.org/10.1016/j.neuron.2020.02.035
PubMed:	View item in PubMed

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