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Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina

Item Type:Article
Title:Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina
Creators Name:Faissner, S. and Graz, F. and Reinehr, S. and Petrikowski, L. and Haupeltshofer, S. and Ceylan, U. and Stute, G. and Winklmeier, S. and Pache, F. and Paul, F. and Ruprecht, K. and Meinl, E. and Dick, H.B. and Gold, R. and Kleiter, I. and Joachim, S.C.
Abstract:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune-inflammatory CNS disease affecting spinal cord and optic nerves, mediated by autoantibodies against aquaporin-4 (AQP4) and myelin-oligodendrocyte-glycoprotein (MOG). Effects of those immunoglobulins (Ig) on retina and optic nerve are incompletely understood. We investigated AQP4-IgG and MOG-IgG sera on retina and optic nerve ex vivo and in 2D2 mice, which harbor a transgenic MOG-specific T-cell receptor. Some sera reacted with murine retina and optic nerve showing distinct binding patterns, suggesting different epitopes being targeted in both subgroups. Transfer of total IgG from a MOG-IgG positive patient to 2D2 mice did neither enhance disability nor induce functional or histological alterations in the retina.
Keywords:Neuromyelitis Optica Spectrum Disorder, Optic Nerve, Retina, Myelin-Oligodendrocyte-Glycoprotein, Aquaporin-4, Autoimmunity, Animals, Mice
Source:Journal of Neuroimmunology
ISSN:0165-5728
Publisher:Elsevier
Volume:342
Page Range:577194
Date:15 May 2020
Official Publication:https://doi.org/10.1016/j.jneuroim.2020.577194
PubMed:View item in PubMed

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