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Keeping the proportions of protein complex components in check

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Item Type:Review
Title:Keeping the proportions of protein complex components in check
Creators Name:Taggart, J.C. and Zauber, H. and Selbach, M. and Li, G.W. and McShane, E.
Abstract:How do cells maintain relative proportions of protein complex components? Advances in quantitative, genome-wide measurements have begun to shed light onto the roles of protein synthesis and degradation in establishing the precise proportions in living cells: on the one hand, ribosome profiling studies indicate that proteins are already produced in the correct relative proportions. On the other hand, proteomic studies found that many complexes contain subunits that are made in excess and subsequently degraded. Here, we discuss these seemingly contradictory findings, emerging principles, and remaining open questions. We conclude that establishing precise protein levels involves both coordinated synthesis and post-translational fine-tuning via protein degradation.
Source:Cell Systems
ISSN:2405-4712
Publisher:Cell Press / Elsevier
Volume:10
Number:2
Page Range:125-132
Date:26 February 2020
Official Publication:https://doi.org/10.1016/j.cels.2020.01.004
PubMed:View item in PubMed

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