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| Item Type: | Article |
|---|---|
| Title: | Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses |
| Creators Name: | Maglione, M. and Kochlamazashvili, G. and Eisenberg, T. and Rácz, B. and Michael, E. and Toppe, D. and Stumpf, A. and Wirth, A. and Zeug, A. and Müller, F.E. and Moreno-Velasquez, L. and Sammons, R.P. and Hofer, S.J. and Madeo, F. and Maritzen, T. and Maier, N. and Ponimaskin, E. and Schmitz, D. and Haucke, V. and Sigrist, S.J. |
| Abstract: | Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in Drosophila. Here we demonstrate that dietary spermidine protects from age-related synaptic alterations at hippocampal mossy fiber (MF)-CA3 synapses and prevents the aging-induced loss of neuronal mitochondria. Dietary spermidine rescued age-dependent decreases in synaptic vesicle density and largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses (MF-CA3) in aged animals. In contrast, spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology. Our data demonstrate that dietary spermidine attenuates age-associated deterioration of MF-CA3 synaptic transmission and plasticity. These findings provide a physiological and molecular basis for the future therapeutic usage of spermidine. |
| Keywords: | Aging, Hippocampal CA3 Region, Hippocampal Mossy Fibers, Long-Term Potentiation, Spermidine, Synaptic Transmission, Synaptic Vesicles, Animals, Mice |
| Source: | Scientific Reports |
| ISSN: | 2045-2322 |
| Publisher: | Nature Publishing Group |
| Volume: | 9 |
| Number: | 1 |
| Page Range: | 19616 |
| Date: | 23 December 2019 |
| Official Publication: | https://doi.org/10.1038/s41598-019-56133-3 |
| PubMed: | View item in PubMed |
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