Genotyping single-nucleotide polymorphisms by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry

Item Type:	Review
Title:	Genotyping single-nucleotide polymorphisms by matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry
Creators Name:	Sauer, S. and Gut, I.G.
Abstract:	In recent years matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI) has emerged as a very powerful method for genotyping single nucleotide polymorphisms. The accuracy, speed of data accumulation, and data structure are the major features of MALDI. Several SNP genotyping methods have been implemented with a high degree of automation and are being applied for large-scale association studies. Most methods for SNP genotyping using MALDI mass spectrometric detection and their potential application for high-throughput are reviewed here.
Keywords:	Reviews, Single-Nucleotide Polymorphism, Genotyping, DNA
Source:	Journal of Chromatography B
ISSN:	0378-4347
Publisher:	Elsevier
Volume:	782
Number:	1-2
Page Range:	73-87
Date:	25 December 2002
Official Publication:	https://doi.org/10.1016/S1570-0232(02)00692-X
PubMed:	View item in PubMed

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