Toward (19)F magnetic resonance thermometry: spin-lattice and spin-spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T

Item Type:	Article
Title:	Toward (19)F magnetic resonance thermometry: spin-lattice and spin-spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T
Creators Name:	Prinz, C. and Delgado, P.R. and Eigentler, T.W. and Starke, L. and Niendorf, T. and Waiczies, S.
Abstract:	OBJECTIVE: This study examines the influence of the environmental factor temperature on the (19)F NMR characteristics of fluorinated compounds in phantom studies and in tissue. MATERIALS AND METHODS: (19)F MR mapping and MR spectroscopy techniques were used to characterize the (19)F NMR characteristics of perfluoro-crown ether (PFCE), isoflurane, teriflunomide, and flupentixol. T(1) and T(2) mapping were performed, while temperature in the samples was changed (T = 20-60 °C) and monitored using fiber optic measurements. In tissue, T(1) of PFCE nanoparticles was determined at physiological temperatures and compared with the T(1)-measured at room temperature. RESULTS: Studies on PFCE, isoflurane, teriflunomide, and flupentixol showed a relationship between temperature and their physicochemical characteristics, namely, chemical shift, T(1) and T(2). T(1) of PFCE nanoparticles was higher at physiological body temperatures compared to room temperature. DISCUSSION: The impact of temperature on the (19)F NMR parameters of fluorinated compounds demonstrated in this study not only opens a trajectory toward (19)F MR-based thermometry, but also indicates the need for adapting MR sequence parameters according to environmental changes such as temperature. This will be an absolute requirement for detecting fluorinated compounds by (19)F MR techniques in vivo.
Keywords:	Magnetic Resonance, Fluorine MR, 19F MR, Thermometry, Spin-Lattice Relaxation, Animals, Mice
Source:	Magnetic Resonance Materials in Physics Biology and Medicine
ISSN:	0968-5243
Publisher:	Springer
Volume:	32
Number:	1
Page Range:	51-61
Date:	February 2019
Official Publication:	https://doi.org/10.1007/s10334-018-0722-8
PubMed:	View item in PubMed

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