![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
|
PDF (Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
621kB | |
![[img]](http://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supporting Information)
5MB |
| Item Type: | Article |
|---|---|
| Title: | 7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions |
| Creators Name: | Behrens, J.R. and Wanner, J. and Kuchling, J. and Ostendorf, L. and Harms, L. and Ruprecht, K. and Niendorf, T. and Jarius, S. and Wildemann, B. and Gieß, R.M. and Scheel, M. and Bellmann-Strobl, J. and Wuerfel, J. and Paul, F. and Sinnecker, T. |
| Abstract: | BACKGROUND: Baló's concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia-induced tissue injury and chemotactic stimuli have been proposed as potential causes of BCS lesion formation. BCS has been suggested to be a variant of multiple sclerosis (MS). Here, we aimed to elucidate similarities and differences between BCS and MS by describing lesion morphology and localization in high-resolution 7 Tesla (7 T) magnetic resonance imaging (MRI) scans. METHODS: Ten patients with Baló-type lesions underwent 7 T MRI, and 10 relapsing remitting MS patients served as controls. The 7 T MR imaging protocol included 3D T(1)-weighted (T(1)w) magnetization-prepared rapid gradient echo, 2D high spatial resolution T(2)*-weighted (T(2)*w) fast low-angle shot and susceptibility-weighted imaging. RESULTS: Intralesional veins were visible in the center of all but one Baló-type lesion. Four Baló-type lesions displayed inhomogeneous intralesional T(2)*w signal intensities, which are suggestive of microhemorrhages or small ectatic venules. Eight of 10 BCS patients presented with 97 additional lesions, 36 of which (37%) had a central vein. Lesions involving the cortical gray matter and the U-fibers were not detected in BCS patients. CONCLUSION: Our findings support the hypothesis that BCS and MS share common pathogenetic mechanisms but patients present with different lesion phenotypes. |
| Source: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Publisher: | Wiley-Blackwell |
| Volume: | 5 |
| Number: | 8 |
| Page Range: | 900-912 |
| Date: | August 2018 |
| Official Publication: | https://doi.org/10.1002/acn3.572 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
