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Assessment of blood brain barrier leakage with gadolinium-enhanced MRI

Item Type:Article
Title:Assessment of blood brain barrier leakage with gadolinium-enhanced MRI
Creators Name:Ku, M.C. and Waiczies, S. and Niendorf, T. and Pohlmann, A.
Abstract:The integrity of the blood-brain barrier (BBB) can be noninvasively monitored by magnetic resonance imaging (MRI). Conventional MR contrast agents (CAs) containing gadolinium are used in association with MRI in routine clinical practice to detect and quantify BBB leakage. Under normal circumstances CAs do not cross the intact BBB. However due to their small size they extravasate from the blood into the brain tissue even when the BBB is partially compromised. Here we describe an MR method based on T1-weighted images taken prior to and after CA injection. This MR method is useful for investigating BBB permeability in in vivo mouse models and can be easily applied in a number of experimental disease conditions including neuroinflammation disorders, or to assess (un)wanted drug effects.
Keywords:Magnetic Resonance Imaging (MRI), Blood Brain Barrier (BBB), Contrast Agent (CA), Animals, Mice
Source:Methods in Molecular Biology
Series Name:Methods in Molecular Biology
Title of Book:Preclinical MRI
Publisher:Springer / Humana Press
Page Range:395-408
Official Publication:https://doi.org/10.1007/978-1-4939-7531-0_23
PubMed:View item in PubMed

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