Helmholtz Gemeinschaft


Evolutionary plasticity in the innate immune function of Akirin

PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
Item Type:Preprint
Title:Evolutionary plasticity in the innate immune function of Akirin
Creators Name:Polanowska, J. and Chen, J.X. and Soule, J. and Omi, S. and Belougne, J. and Taffoni, C. and Pujol, N. and Selbach, M. and Zugasti, O. and Ewbank, J.J.
Abstract:Eukaryotic gene expression requires the coordinated action of transcription factors, chromatin remodelling complexes and RNA polymerase. The conserved nuclear protein Akirin plays a central role in immune gene expression in insects and mammals, linking the SWI/SNF chromatin-remodelling complex with the transcription factor NF{kappa}B. Although nematodes lack NF{kappa}B, Akirin is also indispensable for the expression of defence genes in the epidermis of Caenorhabditis elegans following natural fungal infection. Through a combination of reverse genetics and biochemistry, we discovered that in C. elegans Akirin has conserved its role of bridging chromatin-remodellers and transcription factors, but that the identity of its functional partners is different since it forms a physical complex with NuRD proteins and the POU-class transcription factor CEH-18. In addition to providing a substantial step forward in our understanding of innate immune gene regulation in C. elegans, our results give insight into the molecular evolution of lineage-specific signalling pathways.
Keywords:Antimicrobial Peptide, Chromatin Remodelling, Gene Expression, Innate Immunity, Signal Transduction
Publisher:Cold Spring Harbor Laboratory Press
Article Number:230102
Date:6 December 2017
Official Publication:https://doi.org/10.1101/230102
Related to:
https://edoc.mdc-berlin.de/17615/Final version

Repository Staff Only: item control page


Downloads per month over past year

Open Access
MDC Library