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NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types

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Item Type:Article
Title:NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types
Creators Name:Krieger, K. and Millar, S.E. and Mikuda, N. and Krahn, I. and Kloepper, J.E. and Bertolini, M. and Scheidereit, C. and Paus, R. and Schmidt-Ullrich, R.
Abstract:The transcription factor NF-κB controls key features of hair follicle (HF) development, but the role of NF-κB in adult HF cycle regulation remains obscure. Using NF-κB reporter mouse models, strong NF-κB activity was detected in the secondary hair germ (SHG) of late telogen and early anagen HFs, suggesting a potential role for NF-κB in HF stem/progenitor cell activation during anagen induction. At mid-anagen, NF-κB activity was observed in the inner root sheath (IRS) and unilaterally clustered in the HF matrix, which indicates that NF-κB activity is also involved in hair fiber morphogenesis during HF cycling. A mouse model with inducible NF-κB suppression in the epithelium revealed pelage hair-type-dependent functions of NF-κB in cycling HFs. NF-κB participates in telogen-anagen transition in awl and zigzag HFs, and is required for zigzag hair bending and guard HF cycling. Interestingly, zigzag hair shaft bending depends on non-canonical NF-κB signaling, which previously has only been associated with lymphoid cell biology. Furthermore, loss of guard HF cycling suggests that in this particular hair type NF-κB is indispensable for stem cell activation, maintenance and/or growth.
Keywords:Animal, Models, Gene Expression Regulation, Hair Follicle, Morphogenesis, NF-kappa B, Signal Transduction, Stem Cells, Transgenic, Mice, Animals, Mice
Source:Journal of Investigative Dermatology
Page Range:256-264
Date:February 2018
Additional Information:Erratum in: J Invest Dermatol 138(9): 2084 / Copyright © 2017 The Authors. Published by Elsevier, Inc. on behalf of the Society for lnvestigative Dermatology. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Official Publication:https://doi.org/10.1016/j.jid.2017.08.042
PubMed:View item in PubMed

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