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| Item Type: | Article |
|---|---|
| Title: | How to tame an endogenous retrovirus: HERVH and the evolution of human pluripotency |
| Creators Name: | Römer, C. and Singh, M. and Hurst, L.D. and Izsvák, Z. |
| Abstract: | HERVH is one of the most successful endogenous retrovirus in the human genome. Relative to other endogenous retroviruses, slower degradation of HERVH internal sequences indicates their potential relevance for the host. HERVH is transcriptionally active during human preimplantation embryogenesis. In this review, we focus on the role of HERVH in regulating human pluripotency. The HERVH-mediated pluripotency network has been evolved recently in primates. Nevertheless, it became an essential feature of human pluripotency. We discuss how HERVH modulates the human pluripotency network by providing alternative transcription factor binding sites, functioning as a long-range enhancer, and as being a major source for pluripotency specific long non-coding RNAs and chimeric transcripts. |
| Keywords: | DNA Transposable Elements, Embryonic Development, Endogenous Retroviruses, Evolution, Molecular, Gene Expression Regulation, Viral, Genome, Human, Pluripotent Stem Cells, RNA, Long Noncoding, Transcription Factors, Transcriptional Activation, Animals, Primates |
| Source: | Current Opinion in Virology |
| ISSN: | 1879-6257 |
| Publisher: | Elsevier |
| Volume: | 25 |
| Page Range: | 49-58 |
| Date: | August 2017 |
| Additional Information: | Copyright © 2017, Elsevier. Erratum in: Curr Opin Virol volume 42 Page 66-66 Special Issue: SI |
| Official Publication: | https://doi.org/10.1016/j.coviro.2017.07.001 |
| PubMed: | View item in PubMed |
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