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Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders

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Item Type:Article
Title:Rats overexpressing the dopamine transporter display behavioral and neurobiological abnormalities with relevance to repetitive disorders
Creators Name:Hadar, R. and Edemann-Callesen, H. and Reinel, C. and Wieske, F. and Voget, M. and Popova, E. and Sohr, R. and Avchalumov, Y. and Priller, J. and van Riesen, C. and Puls, I. and Bader, M. and Winter, C.
Abstract:The dopamine transporter (DAT) plays a pivotal role in maintaining optimal dopamine signaling. DAT-overactivity has been linked to various neuropsychiatric disorders yet so far the direct pathological consequences of it has not been fully assessed. We here generated a transgenic rat model that via pronuclear microinjection overexpresses the DAT gene. Our results demonstrate that DAT-overexpression induces multiple neurobiological effects that exceeded the expected alterations in the corticostriatal dopamine system. Furthermore, transgenic rats specifically exhibited behavioral and pharmaco-therapeutic profiles phenotypic of repetitive disorders. Together our findings suggest that the DAT rat model will constitute a valuable tool for further investigations into the pathological influence of DAT overexpression on neural systems relevant to neuropsychiatric disorders.
Keywords:Animal Disease Models, Dopamine Plasma Membrane Transport Proteins, Microinjections, Nervous System Diseases, Transgenic Rats, Up-Regulation, Animals, Mice, Rats
Source:Scientific Reports
ISSN:2045-2322
Publisher:Nature Publishing Group (U.K.)
Volume:6
Page Range:39145
Date:15 December 2016
Official Publication:https://doi.org/10.1038/srep39145
PubMed:View item in PubMed

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