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| Item Type: | Review |
|---|---|
| Title: | LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease |
| Creators Name: | Christ, A. and Herzog, K. and Willnow, T.E. |
| Abstract: | To fulfill their multiple roles in organ development and adult tissue homeostasis Hedgehog morphogens (HH) act through their receptor Patched (PTCH) on target cells. However, HH actions also require HH binding proteins, auxiliary cell surface receptors that agonize or antagonize morphogen signaling in a context-dependent manner. Here, we discuss recent findings on the LDL receptor-related protein 2 (LRP2), an exemplary HH binding protein that modulates sonic hedgehog activities in stem and progenitor cell niches in embryonic and adult tissues. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans. |
| Keywords: | LDL Receptor Related Proteins, Sonic Hedgehog, Morphogen Signaling, Hedgehog Binding Proteins, Endocytosis, Holoprosencephaly, LRP2, Forebrain Development, Donnai-Barrow Syndrome, Animals |
| Source: | Developmental Dynamics |
| ISSN: | 1058-8388 |
| Publisher: | Wiley-Blackwell |
| Volume: | 245 |
| Number: | 5 |
| Page Range: | 569-579 |
| Date: | May 2016 |
| Official Publication: | https://doi.org/10.1002/dvdy.24394 |
| PubMed: | View item in PubMed |
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