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| Item Type: | Editorial |
|---|---|
| Title: | Rsp5/Nedd4 clears cells of heat-damaged proteins |
| Creators Name: | Sommer, T. and Weber, A. and Jarosch, E. |
| Abstract: | Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat. |
| Keywords: | Endosomal Sorting Complexes Required for Transport, HSP40 Heat-Shock Proteins, Heat-Shock Response, Protein Folding, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Ubiquitin-Protein Ligase Complexes, Ubiquitin-Protein Ligases, Animals |
| Source: | Nature Cell Biology |
| ISSN: | 1465-7392 |
| Publisher: | Nature Publishing Group |
| Volume: | 16 |
| Number: | 12 |
| Page Range: | 1130-1132 |
| Date: | 1 December 2014 |
| Official Publication: | https://doi.org/10.1038/ncb3079 |
| PubMed: | View item in PubMed |
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