Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: a combined optical coherence tomography and diffusion tensor imaging study

Item Type:	Article
Title:	Retinal nerve fibre layer thickness correlates with brain white matter damage in multiple sclerosis: a combined optical coherence tomography and diffusion tensor imaging study
Creators Name:	Scheel, M. and Finke, C. and Oberwahrenbrock, T. and Freing, A. and Pech, L.M. and Schlichting, J. and Sömmer, C. and Wuerfel, J. and Paul, F. and Brandt, A.U.
Abstract:	We investigated the association of retinal nerve fibre layer thickness (RNFL) with white matter damage assessed by diffusion tensor imaging (DTI). Forty-four MS patients and 30 healthy subjects underwent optical coherence tomography. DTI was analysed with a voxel-based whole brain and region-based analysis of optic radiation, corpus callosum and further white matter. Correlations between RNFL, fractional anisotropy (FA) and other DTI-based parameters were assessed in patients and controls. RNFL correlated with optic radiation FA, but also with corpus callosum and remaining white matter FA. Our findings demonstrate that RNFL changes indicate white matter damage exceeding the visual pathway.
Keywords:	Multiple Sclerosis, Optical Coherence Tomography, Diffusion Tensor Imaging, Optic Nerve, Optic Radiation, Retina
Source:	Multiple Sclerosis Journal
ISSN:	1352-4585
Publisher:	Sage Publications
Volume:	20
Number:	14
Page Range:	1904-1907
Date:	December 2014
Official Publication:	https://doi.org/10.1177/1352458514535128
PubMed:	View item in PubMed

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