Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: initial experience

Item Type:	Article
Title:	Assessment of tumor microcirculation with dynamic contrast-enhanced MRI in patients with esophageal cancer: initial experience
Creators Name:	Oberholzer, K. and Pohlmann, A. and Schreiber, W. and Mildenberger, P. and Kunz, P. and Schmidberger, H. and Junginger, T. and Dueber, C.
Abstract:	PURPOSE: To investigate the feasibility and impact of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on tumor characterization and response to radiochemotherapy (RCT) in patients with esophageal cancer. MATERIALS AND METHODS: A total of 48 patients underwent DCE-MRI to assess tumor microcirculation based on a two-compartment model function. Effects of RCT on kinetic parameters were studied in 12 patients with squamous cell carcinoma. RESULTS: Tumor microcirculation differs with respect to histological subtype: squamous cell carcinomas showed lower values of amplitude A (leakage space, P = 0.015) and higher contrast agent exchange rates (k(21), P = 0.225) compared with adenocarcinomas. RCT led to a significant decrease of the contrast agent exchange rate (P = 0.005), while amplitude A increased moderately after therapy (P = 0.136). CONCLUSION: DCE-MRI is feasible in patients with esophageal cancer, reveals therapeutic effects, and may thus be useful in therapy management and monitoring.
Keywords:	Esophageal Cancer, Dynamic Contrast-Enhanced MRI, Tumor Microcirculation, Histopathology, Radiochemotherapy
Source:	Journal of Magnetic Resonance Imaging
ISSN:	1053-1807
Publisher:	Wiley-Blackwell
Volume:	27
Number:	6
Page Range:	1296-1301
Date:	June 2008
Official Publication:	https://doi.org/10.1002/jmri.21305
PubMed:	View item in PubMed

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