Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels

Item Type:	Article
Title:	Mediation of hippocampal mossy fiber long-term potentiation by presynaptic Ih channels
Creators Name:	Mellor, J. and Nicoll, R.A. and Schmitz, D.
Abstract:	Hippocampal mossy fiber long-term potentiation (LTP) is expressed presynaptically, but the exact mechanisms remain unknown. Here, we demonstrate the involvement of the hyperpolarization-activated cation channel (Ih) in the expression of mossy fiber LTP. Established LTP was blocked and reversed by Ih channel antagonists. Whole-cell recording from granule cells revealed that repetitive stimulation causes a calcium- and Ih-dependent long-lasting depolarization mediated by protein kinase A. Depolarization at the terminals would be expected to enhance transmitter release, whereas somatic depolarization would enhance the responsiveness of granule cells to afferent input. Thus, Ih channels play an important role in the long-lasting control of transmitter release and neuronal excitability.
Keywords:	Adenylate Cyclase, Benzazepines, Calcium, Chlorides, Cyclic AMP, Cyclic AMP-Dependent Protein Kinases, Cyclic Nucleotide-Gated Cation Channels, Dentate Gyrus, Forskolin, Hippocampal Mossy Fibers, Ion Channels, Isoquinolines, Long-Term Potentiation, Membrane Potentials, Membrane Proteins, Nerve Tissue Proteins, Neurological Models, Patch-Clamp Techniques, Potassium, Potassium Channels, Presynaptic Terminals, Pyramidal Cells, Pyrimidines, Sulfonamides, Synaptic Transmission, Animals, Rats
Source:	Science
ISSN:	0036-8075
Publisher:	American Association for the Advancement of Science
Volume:	295
Number:	5552
Page Range:	143-147
Date:	4 January 2002
Official Publication:	https://doi.org/10.1126/science.1064285
PubMed:	View item in PubMed

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