The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis

Item Type:	Review
Title:	The neutrophil in antineutrophil cytoplasmic autoantibody-associated vasculitis
Creators Name:	Schreiber, A. and Kettritz, R.
Abstract:	Necrotizing, small-vessel vasculitis develops in patients with circulating ANCAs. Neutrophils and monocytes harbor the two major ANCA antigens, PR3 and MPO. A whole body of in vitro experiments implicated ANCA-activated neutrophil effector functions in the pathogenesis of vasculitis, whereas the role of monocytes is less well-characterized. Mouse models for anti-MPO-induced vasculitis were developed to study ANCA-neutrophil interactions in complex in vivo situations. We not only discuss the significance of ANCA-neutrophil interactions for disease induction but also how a detailed understanding of these interactions helps to identify novel treatment targets for ANCA vasculitis.
Keywords:	Inflammation, ANCA, Animal Model, Crescentic Glomerulonephritis, Animals
Source:	Journal of Leukocyte Biology
ISSN:	0741-5400
Publisher:	Society for Leukocyte Biology
Volume:	94
Number:	4
Page Range:	623-631
Date:	October 2013
Official Publication:	https://doi.org/10.1189/jlb.1012525
PubMed:	View item in PubMed

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