Cardiovascular risk markers in pregnancies complicated by diabetes mellitus or preeclampsia

Item Type:	Article
Title:	Cardiovascular risk markers in pregnancies complicated by diabetes mellitus or preeclampsia
Creators Name:	Sugulle, M. and Herse, F. and Seiler, M. and Dechend, R. and Staff, A.C.
Abstract:	Objective: To explore biomarkers indicating cardiovascular disease in pregnant women with diabetes or preeclampsia, since these women are at increased risk for future cardiovascular disease. Study design: EDTA-plasma from 262 women in gestational week 24-42 (healthy pregnancies n = 71, preeclampsia n = 105, type 2 diabetes n = 17, gestational diabetes n = 61, diabetes with preeclampsia n = 8) was analyzed by immunoassay for neopterin, midregional pro-adrenomedullin (MR-proADM) and C-terminal pro-arginine vasopressin (CT-proAVP). The diabetes groups were also analyzed for midregional pro-atrial natriuretic peptide (MR-proANP), and compared to previously reported MR-proANP concentrations for healthy, normotensive and preeclamptic patients. Results: In contrast to preeclampsia, median plasma MR-proANP was not increased in pregnancies complicated by diabetes, but in fact lower, compared to healthy pregnancies. Neopterin was increased in diabetic pregnancies and in late onset preeclampsia, compared to healthy pregnancies. Median plasma MR-proADM was increased in pregnancies complicated by gestational diabetes or preeclampsia, compared to healthy pregnancies. Median plasma MR-proANP was increased in diabetic pregnancies complicated by preeclampsia compared to pregnant women with diabetes only. Conclusion: Women with pregnancies complicated by diabetes mellitus or preeclampsia are at risk for future cardiovascular disease, but differ in circulating cardiovascular biomarker profile. A cardiovascular biomarker profiling during pregnancy might prove helpful in identifying women at risk for future cardiovascular disease, thus enabling targeted prophylactic interventions and follow-up.
Keywords:	Preeclampsia, Diabetes Mellitus, Pregnancy, Cardiovascular Disease, Biomarkers
Source:	Pregnancy Hypertension
ISSN:	2210-7789
Publisher:	Elsevier
Volume:	2
Number:	4
Page Range:	403-410
Date:	October 2012
Official Publication:	https://doi.org/10.1016/j.preghy.2012.03.002
PubMed:	View item in PubMed

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