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The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers

Item Type:Article
Title:The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers
Creators Name:Calado, D.P. and Sasaki, Y. and Godinho, S.A. and Pellerin, A. and Köchert, K. and Sleckman, B.P. and de Alboran, I.M. and Janz, M. and Rodig, S. and Rajewsky, K.
Abstract:Germinal centers (GCs) are sites of intense B cell proliferation and are central for T cell-dependent antibody responses. However, the role of c-Myc, a key cell-cycle regulator, in this process has been questioned. Here we identified c-Myc(+) B cell subpopulations in immature and mature GCs and found, by genetic ablation of Myc, that they had indispensable roles in the formation and maintenance of GCs. The identification of these functionally critical cellular subsets has implications for human B cell lymphomagenesis, which originates mostly from GC B cells and frequently involves MYC chromosomal translocations. As these translocations are generally dependent on transcription of the recombining partner loci, the c-Myc(+) GC subpopulations may be at a particularly high risk for malignant transformation.
Keywords:B-Lymphocyte Subsets, B-Lymphocytes, Cell Cycle, Cell Proliferation, Gene Deletion, Gene Expression Regulation, Genetic Loci, Genetic Translocation, Germinal Center, Green Fluorescent Proteins, Lymphoma, Neoplastic Cell Transformation, Proto-Oncogene Proteins c-myc, Reporter Genes, Signal Transduction, T-Lymphocytes, Transgenic Mice, Animals, Mice
Source:Nature Immunology
Publisher:Nature Publishing Group
Page Range:1092-1100
Date:November 2012
Official Publication:https://doi.org/10.1038/ni.2418
PubMed:View item in PubMed

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