![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
![[img]](http://edoc.mdc-berlin.de/style/images/fileicons/application_pdf.png) |
PDF
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
191kB |
| Item Type: | Article |
|---|---|
| Title: | Hypertension in response to IL-6 during pregnancy: role of AT1-receptor activation |
| Creators Name: | Lamarca, B. and Speed, J. and Ray, L.F. and Cockrell, K. and Wallukat, G. and Dechend, R. and Granger, J. |
| Abstract: | BACKGROUND: Increases in interleukin 6 (IL-6) and agonistic autoantibodies to the angiotensin II type 1 receptor (AT1-AA) are proposed to be important links between placental ischemia and hypertension in preeclampsia. METHODS: The purpose of this study was to determine whether IL-6 (5 ng/day), infused into normal pregnant (NP) rats, increased mean arterial pressure (MAP) and AT1-AA. MAP was analyzed in the presence and absence of an angiotensin type 1 receptor (AT1R) antagonist, losartan, L. RESULTS: MAP and AT1-AA increased from 102 ± 2 to 118 ± 4 mmHg and 0.7 ± 0.3 NP to 14.1 ± 1.4 chronotropic units with chronic IL-6 infusion. MAP responses to IL-6 were abolished in losartan pretreated rats (85 ± 4 in NP + L vs 85 ± 3 mmHg in IL-6 + L). CONCLUSION: These data indicate that IL-6 stimulates AT1-AA and that activation of the AT1R mediates IL-6 induced hypertension during pregnancy. |
| Keywords: | Cytokines, Pregnancy, Hypertension, Renin Angiotensin System, Inflammation, Animals, Rats |
| Source: | International Journal of Interferon, Cytokine and Mediator Research |
| ISSN: | 1179-139X |
| Publisher: | Dove Medical Press |
| Volume: | 2011 |
| Number: | 3 |
| Page Range: | 65-70 |
| Date: | 3 November 2011 |
| Official Publication: | https://doi.org/10.2147/IJICMR.S22329 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
Download Statistics
Download Statistics
