Helmholtz Gemeinschaft


Long-term benefits of immunoadsorption in beta(1)-adrenoceptor autoantibody-positive transplant candidates with dilated cardiomyopathy

Item Type:Article
Title:Long-term benefits of immunoadsorption in beta(1)-adrenoceptor autoantibody-positive transplant candidates with dilated cardiomyopathy
Creators Name:Dandel, M. and Wallukat, G. and Englert, A. and Lehmkuhl, H.B. and Knosalla, C. and Hetzer, R.
Abstract:AIMS: Prolongation of waiting times for heart transplantation (HTx) increases the need for new therapies. In short-term follow-up studies, immunoadsorption (IA) appeared beneficial in dilated cardiomyopathy (DCM) associated with beta(1)-adrenoreceptor-autoantibodies (beta(1)-AABs). This study aimed to investigate the long-term benefits of IA in HTx candidates with DCM, patients' responsiveness to IA, and the impact of beta(1)-AAB removal on IA results. METHODS AND RESULTS: In a single-centre retrospective study of prospectively gathered information we evaluated all beta(1)-AAB-positive and -negative HTx candidates with end-stage DCM [left ventricular ejection fraction (LVEF) <30%] who underwent IA between 1995 and 2005 (follow-up thereafter: 5.3-14.7 years). As controls we used all beta(1)-AAB-positive DCM patients referred for HTx during the same time period who received no IA therapy. We also looked for differences in efficacy between unspecific IA (unselective antibody removal) and specific IA (selective beta(1)-AAB removal). The main outcome measures were cardiac function and HTx/ventricular assist device (VAD)-free patient survival. The probability for 5-year HTx/VAD-free survival for the108 beta(1)-AAB-positive DCM patients who underwent unspecific IA reached 69.4 ± 4.4% and was significantly higher (P < 0.05) than for both beta(1)-AAB-positive DCM patients without IA (25.4 ± 11.4%) and beta(1)-AAB-negative DCM patients who also underwent IA (47.4 ± 11.5). In patients with high beta(1)-AAB levels, unspecific and specific IA showed the same high efficiency in beta(1)-AAB removal. LVEF and New York Heart Assocation class improved (P < 0.01) after both, but without differences in improvement after specific or unspecific IA. The prevalence of responders to specific and unspecific IA was similar (78.3% vs. 79.6%). In 76% of the patients with beta(1)-AAB reappearance, redetection of AABs coincided with worsening of cardiac function. CONCLUSIONS: Removal of beta(1)-AABs by specific or unspecific IA can improve cardiac function allowing long-term stability in end-stage DCM, which can spare many patients from HTx or will delay HTx listing for years. In beta(1)-AAB-positive DCM patients the benefits of IA appeared to be associated with the removal of these antibodies.
Keywords:Dilated Cardiomyopathy, Heart Failure, Autoantibodies, Beta(1) Receptors, Immunoadsorption, Survival
Source:European Journal of Heart Failure
Publisher:Oxford University Press
Page Range:1374-1388
Date:December 2012
Official Publication:https://doi.org/10.1093/eurjhf/hfs123
PubMed:View item in PubMed

Repository Staff Only: item control page

Open Access
MDC Library