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| Item Type: | Article |
|---|---|
| Title: | Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of bathyergidae |
| Creators Name: | Smith, E.S.J. and Purfürst, B. and Grigoryan, T. and Park, T.J. and Bennett, N.C. and Lewin, G.R. |
| Abstract: | In mammalian peripheral nerves, unmyelinated C-fibers usually outnumber myelinated A-fibers. Using transmission electron microscopy we recently showed that the saphenous nerve of the naked mole-rat (Heterocephalus glaber) has a C-fiber deficit manifested as a substantially lower C:A-fiber ratio compared to other mammals. Here we determined the uniqueness of this C-fiber deficit by performing a quantitative anatomical analysis of several peripheral nerves in five further members of the Bathyergidae mole-rat family: silvery (Heliophobius argenteocinereus), giant (Fukomys mechowii), Damaraland (Fukomys damarensis), Mashona (Fukomys darlingi) and Natal (Cryptomys hottentotus natalensis) mole-rats. In the largely cutaneous saphenous and sural nerves we found that the naked mole-rat had the lowest C:A-fiber ratio (~1.5:1 compared to ~3:1), whereas in nerves innervating both skin and muscle (common peroneal and tibial) or just muscle (lateral/medial gastrocnemius), this pattern was mostly absent. We asked whether lack of hair follicles alone accounts for the C-fiber paucity using a mouse model, which loses virtually all its hair as a consequence of conditional deletion of the beta-catenin gene in the skin. These beta-catenin loss-of function mice (beta-cat LOF mice) displayed only a mild decrease in C:A-fiber ratio compared to wild-type mice (4.42 compared to 3.81). We suggest that the selective cutaneous C-fiber deficit in the cutaneous nerves of naked mole-rats is unlikely to be primarily due to lack of skin hair follicles. Possible mechanisms contributing to this unique peripheral nerve anatomy are discussed. |
| Keywords: | Naked Mole-Rat, C-Fiber, A-Fiber, Remak Bundle, Nociceptor, Bathyergidae, Animals, Naked Mole-Rats |
| Source: | Journal of Comparative Neurology |
| ISSN: | 0021-9967 |
| Publisher: | Wiley-Blackwell |
| Volume: | 520 |
| Number: | 12 |
| Page Range: | 2785-2803 |
| Date: | 15 August 2012 |
| Official Publication: | https://doi.org/10.1002/cne.23133 |
| PubMed: | View item in PubMed |
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