Dual effect of glucocorticoids on apoptosis of human autoreactive and foreign antigen-specific T cells

Item Type:	Article
Title:	Dual effect of glucocorticoids on apoptosis of human autoreactive and foreign antigen-specific T cells
Creators Name:	Zipp, F. and Wendling, U. and Beyer, M. and Grieger, U. and Waiczies, S. and Wagenknecht, B. and Haas, J. and Weller, M.
Abstract:	The efficacy of glucocorticoids in the treatment of multiple sclerosis may involve the induction of T cell apoptosis. Here, we report that glucocorticoids have two different effects on the vulnerability of human antigen-specific T cells: (i) steroids induce T cell apoptosis in a CD95-independent, but caspase-dependent manner; (ii) steroids protect T cells from CD95-mediated apoptosis which, however, is also caspase-dependent. An increase in BCL-2 expression is observed upon incubation with steroids. Thus, inhibition of CD95-mediated T cell apoptosis may be an undesirable side-effect resulting in survival of activated T cells and the maintenance of pathogenic immune responses might explain the lack of long-term glucocorticoid therapy.
Keywords:	Apoptosis, T Lymphocytes, MS, Autoimmunity, Human
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	110
Number:	1-2
Page Range:	214-222
Date:	2 October 2000
Official Publication:	https://doi.org/10.1016/S0165-5728(00)00337-4
PubMed:	View item in PubMed

Repository Staff Only: item control page