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23Na magnetic resonance imaging of tissue sodium

Item Type:Article
Title:23Na magnetic resonance imaging of tissue sodium
Creators Name:Kopp, C. and Linz, P. and Wachsmuth, L. and Dahlmann, A. and Horbach, T. and Schoefl, C. and Renz, W. and Santoro, D. and Niendorf, T. and Mueller, D.N. and Neininger, M. and Cavallaro, A. and Eckardt, K.U. and Schmieder, R.E. and Luft, F.C. and Uder, M. and Titze, J.
Abstract:Hypertension is linked to disturbed total-body sodium (Na(+)) regulation; however, measuring Na(+) disposition in the body is difficult. We implemented (23)Na magnetic resonance spectroscopy ((23)Na-MR) and imaging technique ((23)Na-MRI) at 9.4T for animals and 3T for humans to quantify Na(+) content in skeletal muscle and skin. We compared (23)Na-MRI data with actual tissue Na(+) content measured by chemical analysis in animal and human tissue. We then quantified tissue Na(+) content in normal humans and in patients with primary aldosteronism. We found a 29% increase in muscle Na(+) content in patients with aldosteronism compared with normal women and men. This tissue Na(+) was mobilized after successful treatment without accompanying weight loss. We suggest that, after further refinements, this tool could facilitate understanding the relationships between Na(+) accumulation and hypertension. Furthermore, with additional technical advances, a future clinical use may be possible.
Keywords:Aldosterone, MRI, Sodium, Hypertension, Animals, Mice, Rats
Publisher:American Heart Association
Page Range:167-172
Date:January 2012
Official Publication:https://doi.org/10.1161/HYPERTENSIONAHA.111.183517
PubMed:View item in PubMed

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