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Tethering toxins and peptide ligands for modulation of neuronal function

Item Type:Article
Title:Tethering toxins and peptide ligands for modulation of neuronal function
Creators Name:Ibanez-Tallon, I. and Nitabach, M.N.
Abstract:Tethering genetically encoded peptide toxins or ligands close to their point of activity at the cell plasma membrane provides a new approach to the study of cell networks and neuronal circuits, as it allows selective targeting of specific cell populations, enhances the working concentration of the ligand or blocker peptide, and permits the engineering of a large variety of t-peptides (e.g., including use of fluorescent markers, viral vectors and point mutation variants). This review describes the development of tethered toxins (t-toxins) and peptides derived from the identification of the cell surface nicotinic acetylcholine receptor (nAChR) modulator lynx1, the existence of related endogenous cell surface modulators of nAChR and AMPA receptors, and the application of the t-toxin and t-neuropeptide technology to the dissection of neuronal circuits in metazoans.
Keywords:Ligands, Neuropeptides, Neurosciences, Neurotoxins, Nicotinic Receptors, Protein Engineering, Animals
Source:Current Opinion in Neurobiology
Page Range:72-78
Date:February 2012
Official Publication:https://doi.org/10.1016/j.conb.2011.11.003
PubMed:View item in PubMed

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