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| Item Type: | Article |
|---|---|
| Title: | E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming |
| Creators Name: | Redmer, T. and Diecke, S. and Grigoryan, T. and Quiroga-Negreira, A. and Birchmeier, W. and Besser, D. |
| Abstract: | We report new functions of the cell-adhesion molecule E-cadherin in murine pluripotent cells. E-cadherin is highly expressed in mouse embryonic stem cells, and interference with E-cadherin causes differentiation. During cellular reprogramming of mouse fibroblasts by OCT4, SOX2, KLF4 and c-MYC, fully reprogrammed cells were exclusively observed in the E-cadherin-positive cell population and could not be obtained in the absence of E-cadherin. Moreover, reprogrammed cells could be established by viral E-cadherin in the absence of exogenous OCT4. Thus, reprogramming requires spatial cues that cross-talk with essential transcription factors. The cell-adhesion molecule E-cadherin has important functions in pluripotency and reprogramming. |
| Keywords: | Pluripotency, Somatic Cell Reprogramming, E-Cadherin, OCT4, Cadherins, Cell Differentiation, Cell Line, Developmental Gene Expression Regulation, Embryonic Stem Cells, Gene Deletion, Messenger RNA, Nuclear Reprogramming, Octamer Transcription Factor-3, Pluripotent Stem Cells, Animals, Mice, 129 Strain Mice, Inbred NOD Mice, SCID Mice |
| Source: | EMBO Reports |
| ISSN: | 1469-221X |
| Publisher: | Nature Publishing Group |
| Volume: | 12 |
| Number: | 7 |
| Page Range: | 720-726 |
| Date: | 1 July 2011 |
| Official Publication: | https://doi.org/10.1038/embor.2011.88 |
| PubMed: | View item in PubMed |
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