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Efficient and detailed model of the local Ca(2+) release unit in the ventricular cardiac myocyte

Item Type:Article
Title:Efficient and detailed model of the local Ca(2+) release unit in the ventricular cardiac myocyte
Creators Name:Schendel, T. and Falcke, M.
Abstract:We present here an efficient but detailed approach to modelling Ca(2+)-induced Ca(2+) release in the diadic cleft of cardiac ventricular myocytes. In this Framework we developed a spatial resolved Ca(2+) release unit (CaRU), consisting of the junctional sarcoplasmic reticulum and the diadic cleft, with a well defined channel placement. By taking advantage of time scale seperation, the model could be finally reduced to only one ordinary differential equation for describing Ca(2+) fluxes and diffusion. Additionally the channel gating is described in a stochastic way. The resulting model is able to reproduce experimental findings like the gradedness of SR release, the voltage dependence of ECC gain and typical spark life time. Due to the numerical efficience of the model, it is suitable to use for whole cell simulations. The approach we want to use extend the developed (CaRU) to such a whole cell model is already outlined in this work.
Keywords:Excitation-Contraction Coupling, Calcium Dynamics, Modelling, Animals
Source:Genome Informatics
ISSN:0919-9454
Publisher:Universal Academy Press (Japan)
Volume:22
Number:1
Page Range:142-155
Date:January 2010
PubMed:View item in PubMed

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