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The hair follicle as a dynamic miniorgan

Official URL:https://doi.org/10.1016/j.cub.2008.12.005
PubMed:View item in PubMed
Creators Name:Schneider, M.R. and Schmidt-Ullrich, R. and Paus, R.
Journal Title:Current Biology
Journal Abbreviation:Curr Biol
Volume:19
Number:3
Page Range:R132-T142
Date:10 February 2009
Keywords:Hair Diseases, Hair Follicle, Morphogenesis, Stem Cells, Animals, Mice
Abstract:Hair is a primary characteristic of mammals, and exerts a wide range of functions including thermoregulation, physical protection, sensory activity, and social interactions. The hair shaft consists of terminally differentiated keratinocytes that are produced by the hair follicle. Hair follicle development takes place during fetal skin development and relies on tightly regulated ectodermal-mesodermal interactions. After birth, mature and actively growing hair follicles eventually become anchored in the subcutis, and periodically regenerate by spontaneously undergoing repetitive cycles of growth (anagen), apoptosis-driven regression (catagen), and relative quiescence (telogen). Our molecular understanding of hair follicle biology relies heavily on mouse mutants with abnormalities in hair structure, growth, and/or pigmentation. These mice have allowed novel insights into important general molecular and cellular processes beyond skin and hair biology, ranging from organ induction, morphogenesis and regeneration, to pigment and stem cell biology, cell proliferation, migration and apoptosis. In this review, we present basic concepts of hair follicle biology and summarize important recent advances in the field.
ISSN:0960-9822
Publisher:Cell Press (U.S.A.)
Item Type:Review

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