Helmholtz Gemeinschaft


Channelopathies of transepithelial transport and vesicular function

Item Type:Review
Title:Channelopathies of transepithelial transport and vesicular function
Creators Name:Huebner, C.A. and Jentsch, T.J.
Abstract:The transport of ions across cellular membranes is crucial for various functions, including the transport of salt and water across epithelia, the control of electrical excitability of muscle and nerve, and the regulation of cell volume or the acidification and ionic homeostasis of intracellular organelles. This review will focus on ion channel diseases (channelopathies) that are due to impaired transepithelial transport or due to mutations in vesicular ion transporters or channels. When needed for a more comprehensive understanding of organ function, also other ion transport diseases will be mentioned.
Keywords:Biological Transport, Channelopathies, Epithelial Cells, Kidney, Transport Vesicles, Animals
Source:Advances in Genetics
Publisher:Elsevier (The Netherlands)
Page Range:113-152
Official Publication:https://doi.org/10.1016/S0065-2660(08)01005-5
PubMed:View item in PubMed

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