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Identification of brain- and bone-specific breast cancer metastasis genes

Item Type:Article
Title:Identification of brain- and bone-specific breast cancer metastasis genes
Creators Name:Klein, A. and Olendrowitz, C. and Schmutzler, R. and Hampl, J. and Schlag, P.M. and Maass, N. and Arnold, N. and Wessel, R. and Ramser, J. and Meindl, A. and Scherneck, S. and Seitz, S.
Abstract:In breast cancer, metastases are relatively widely distributed, with the most common sites being bone, regional lymph nodes, lung, liver, and brain. The detailed mechanism of organ-specific metastasis is poorly understood. In this study, we initiated a search for genes that are implicated in brain or bone metastasis of primary human breast cancer. We generated gene expression profiles of 18 brain and eight bone metastases derived from primary breast tumors. We identified 73 genes differentially expressed between brain and bone metastases. Visualization of the differential gene expression profiles by correspondence and cluster analyses shows that the metastases clearly separate into two distinct groups as an exact reflection of their site of metastasis. Moreover, the analysis of this gene set in primary breast tumors relapsing to either bone or brain allowed accurate categorization of the tumors according to their metastatic site. The identified genes may prove to be excellent markers to predict the site of metastasis in breast cancer patients and could lead to tailor-made therapy to an individual patient.
Keywords:Breast Cancer, Brain Metastases, Bone Metastases, Microarray, Gene Expression Profiling, Carrier Proteins, Cluster Analysis, Estrogen Receptor alpha, Matrix Metalloproteinase 13, Membrane Proteins, Organ Specificity
Source:Cancer Letters
Page Range:212-220
Date:18 April 2009
Official Publication:https://doi.org/10.1016/j.canlet.2008.11.017
PubMed:View item in PubMed

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