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Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11

Item Type:Article
Title:Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11
Creators Name:Spoelgen, R. and Adams, K.W. and Koker, M. and Thomas, A.V. and Andersen, O.M. and Hallett, P.J. and Bercury, K.K. and Joyner, D.F. and Deng, M. and Stoothoff, W.H. and Strickland, D.K. and Willnow, T.E. and Hyman, B.T.
Abstract:In this study, we examined protein-protein interactions between two neuronal receptors, low density lipoprotein receptor-related protein (LRP) and sorLA/LR11, and found that these receptors interact, as indicated by three independent lines of evidence: co-immunoprecipitation experiments, surface plasmon resonance analysis, and fluorescence lifetime imaging microscopy (FLIM). Immunocytochemistry experiments revealed widespread co-localization of LRP and sorLA within perinuclear compartments of neurons, while FLIM analysis showed that LRP-sorLA interactions take place within a subset of these compartments.
Keywords:LRP, sorLA, LR11, LDL Receptor, Animals, Mice, Rats
Source:Neuroscience
ISSN:0306-4522
Publisher:Elsevier (The Netherlands)
Volume:158
Number:4
Page Range:1460-1468
Date:18 February 2009
Official Publication:https://doi.org/10.1016/j.neuroscience.2008.10.061
PubMed:View item in PubMed

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