Item Type: | Article |
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Title: | Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11 |
Creators Name: | Spoelgen, R. and Adams, K.W. and Koker, M. and Thomas, A.V. and Andersen, O.M. and Hallett, P.J. and Bercury, K.K. and Joyner, D.F. and Deng, M. and Stoothoff, W.H. and Strickland, D.K. and Willnow, T.E. and Hyman, B.T. |
Abstract: | In this study, we examined protein-protein interactions between two neuronal receptors, low density lipoprotein receptor-related protein (LRP) and sorLA/LR11, and found that these receptors interact, as indicated by three independent lines of evidence: co-immunoprecipitation experiments, surface plasmon resonance analysis, and fluorescence lifetime imaging microscopy (FLIM). Immunocytochemistry experiments revealed widespread co-localization of LRP and sorLA within perinuclear compartments of neurons, while FLIM analysis showed that LRP-sorLA interactions take place within a subset of these compartments. |
Keywords: | LRP, sorLA, LR11, LDL Receptor, Animals, Mice, Rats |
Source: | Neuroscience |
ISSN: | 0306-4522 |
Publisher: | Elsevier |
Volume: | 158 |
Number: | 4 |
Page Range: | 1460-1468 |
Date: | 18 February 2009 |
Official Publication: | https://doi.org/10.1016/j.neuroscience.2008.10.061 |
PubMed: | View item in PubMed |
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