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Cardiovascular magnetic resonance imaging detects cardiac involvement in churg-strauss syndrome

Item Type:Article
Title:Cardiovascular magnetic resonance imaging detects cardiac involvement in churg-strauss syndrome
Creators Name:Wassmuth, R. and Goebel, U. and Natusch, A. and Schneider, W. and Kettritz, R. and Dietz, R. and Luft, F.C. and Schulz-Menger, J.
Abstract:BACKGROUND: Cardiac involvement in Churg-Strauss vasculitis worsens the prognosis. Early detection is, therefore, warranted. Cardiac magnetic resonance (CMR) can visualize various forms of inflammatory changes in the myocardium. We tested whether CMR could elucidate cardiac damage in patients with biopsy-proven Churg-Strauss syndrome and clinical evidence of cardiac involvement. METHODS AND RESULTS: Eleven patients underwent a CMR protocol including cine imaging for left ventricular function in long axes, T2-weighted imaging for edema detection, and contrast-enhanced T1-weighting for early and late gadolinium enhancement. CMR detected various form of myocardial injury in all patients. Systolic left ventricular function was impaired in 6 patients. Mean left ventricular ejection fraction was 45 +/- 15%. Left ventricular size was mildly enlarged (left ventricular end-diastolic volume index 94 +/- 23 mL/m(2)). Edema was present in 4 cases; 7 patients had pericardial effusion. Six patients had increased early contrast uptake. CMR detected late enhancement lesions in 9 of 11 patients, even in those with normal left ventricular size and function. CONCLUSIONS: CMR has the potential to detect myocardial injury in Churg-Strauss syndrome even when left ventricular function appears normal.
Keywords:Vasculitis, Cardiomyopathy, Myocarditis, Contrast
Source:Journal of Cardiac Failure
Page Range:856-860
Date:December 2008
Official Publication:https://doi.org/10.1016/j.cardfail.2008.07.227
PubMed:View item in PubMed

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